American Diabetes Association 60th Scientific Sessions, 2000
2001; American Diabetes Association; Volume: 24; Issue: 3 Linguagem: Inglês
10.2337/diacare.24.3.598
ISSN1935-5548
Autores Tópico(s)Diet and metabolism studies
ResumoThis is the fifth in a continuing series of articles on the American Diabetes Association (ADA) 60th Scientific Sessions held in San Antonio, Texas, in June 2000. It covers topics related to nephropathy. ### Hypertension and Nephropathy A number of studies presented at the meeting gave insight into clinical and pathophysiological aspects of hypertension and nephropathy in patients with diabetes. Tarver-Carr et al. (abstract 783) reported 16-year follow-up analysis of 9,250 adults aged 30–74 in 1976–1980 who participated in the Second National Health and Nutrition Examination Survey (NHANES II). A total of 46 end-stage renal disease cases developed in the 521 diabetic adults, whereas 142 cases developed in those without type 2 diabetes at baseline, with cumulative incidence by age 75 of 7 vs. 3% among men and 8 vs. 0.8% among women with and without diabetes. For type 1 diabetes, Schultz and colleagues (abstracts 652 and 653) analyzed 511 patients developing diabetes before age 16 and followed for a median of 6 years. Of the patients, 63 developed microalbuminuria, showing both higher baseline albuminuria and a correlation of mean HbA1c with the rate of increase of albuminuria, which also increased at a higher rate after onset of puberty. The risk of developing microalbuminuria was doubled for female patients, tripled after onset of puberty, and increased 36% for every 1% increase in HbA1c. Tabak and Orchard (abstract 658) reported greater baseline albuminuria, higher HbA1c, longer diabetes duration, conventional treatment, younger age, male sex, and lower HDL cholesterol in females to be significant predictors of the development of microalbuminuria among 1,367 patients with type 1 diabetes in the Diabetes Control and Complications Trial (DCCT) who were initially normoalbuminuric. Thus, glycemia is an important explanation of diabetic nephropathy, but other factors must play a role in determining susceptibility. Brown et al. …
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