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Subacute toxicity assessment of diflubenzuron, an insect growth regulator, in adult male rats
2014; Wiley; Volume: 31; Issue: 4 Linguagem: Inglês
10.1002/tox.22054
ISSN1522-7278
AutoresAline Lima de Barros, Gabriéla Finoto Cavalheiro, Alexsandra Vila Maior de Souza, Giseli Karenina Traesel, Janete Aparecida Anselmo-Franci, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena,
Tópico(s)Environmental Toxicology and Ecotoxicology
ResumoEnvironmental ToxicologyVolume 31, Issue 4 p. 407-414 Research Article Subacute toxicity assessment of diflubenzuron, an insect growth regulator, in adult male rats Aline Lima de Barros, Aline Lima de Barros School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorGabriela Finoto Cavalheiro, Gabriela Finoto Cavalheiro School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorAlexsandra Vila Maior de Souza, Alexsandra Vila Maior de Souza School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorGiseli Karenina Traesel, Giseli Karenina Traesel School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorJanete A. Anselmo-Franci, Janete A. Anselmo-Franci Department of Physiology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, BrazilSearch for more papers by this authorCândida Aparecida Leite Kassuya, Cândida Aparecida Leite Kassuya School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorArielle Cristina Arena, Corresponding Author Arielle Cristina Arena School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil Department of Morphology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilCorrespondence to: A. C. Arena; e-mail: ariellearena@ibb.unesp.brSearch for more papers by this author Aline Lima de Barros, Aline Lima de Barros School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorGabriela Finoto Cavalheiro, Gabriela Finoto Cavalheiro School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorAlexsandra Vila Maior de Souza, Alexsandra Vila Maior de Souza School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorGiseli Karenina Traesel, Giseli Karenina Traesel School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorJanete A. Anselmo-Franci, Janete A. Anselmo-Franci Department of Physiology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, BrazilSearch for more papers by this authorCândida Aparecida Leite Kassuya, Cândida Aparecida Leite Kassuya School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, BrazilSearch for more papers by this authorArielle Cristina Arena, Corresponding Author Arielle Cristina Arena School of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil Department of Morphology, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), Botucatu, São Paulo, BrazilCorrespondence to: A. C. Arena; e-mail: ariellearena@ibb.unesp.brSearch for more papers by this author First published: 30 September 2014 https://doi.org/10.1002/tox.22054Citations: 11 Disclosure: The authors declare that there are no conflicts of interest. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat ABSTRACT Diflubenzuron (DFB), an insecticide and acaricide insect growth regulator, can be used in agriculture against insect predators and in public health programs, to control insects and vectors, mainly Aedes aegypti larvae. Due to the lack of toxicological assessments of this compound, the objective of the present study was to evaluate the toxicological effects of subacute exposure to the DFB insecticide in adult male rats. Adult male rats were exposed (gavage) to 0, 2, 4, or 8 mg/kg of DFB for 28 days. No clinical signs of toxicity were observed in the DFB-treated animals of the experimental groups. However, there was an increase in serum levels of alanine aminotransferase in the group that received 8 mg/kg/DFB/day and urea at doses of 4 and 8 mg/kg/DFB/day, without altering other biochemical or hematological parameters. The subacute exposure to the lowest dose of DFB caused significant decrease in testis weight, daily sperm production, and in number of sperm in the epididymis in relation to the control group. However, no alterations were observed in the sperm morphology, testicular, epididymis, liver and kidney histology, or testosterone levels. These findings unveiled the hazardous effects of DFB on male reproduction after the subacute exposure and special attention should be addressed to the effects of low doses of this pesticide. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 407–414, 2016. Citing Literature Volume31, Issue4April 2016Pages 407-414 RelatedInformation
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