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Strongyloides ratti: Acquired resistance in the rat to the preintestinal migrating larvae

1980; Elsevier BV; Volume: 50; Issue: 3 Linguagem: Inglês

10.1016/0014-4894(80)90044-2

1090-2449

K. Darwin Murrell,

Child Nutrition and Water Access

Potential sites for expression of acquired resistance to Strongyloides ratti larvae in rats were investigated. In rats immunized by exposure to a single live infection and challenged 30 to 40 days later, 46 to 98% of the challenge larvae failed to reach the small intestine. Multiply immunized rats nearly completely eliminated migrating challenge larvae. This early killing of migrating larvae occurred during the first 48 hr after challenge infection. Resistance to migrating challenge larvae was also induced by repeated injections with heat-killed infective larvae. That the intestine may also serve as an effective site for worm expulsion was confirmed by intestinal transfers of worms from rats with primary infections into resistant rats.