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Development of a Cy3‐Labeled Glucose Bioprobe and Its Application in Bioimaging and Screening for Anticancer Agents

2007; Wiley; Volume: 46; Issue: 12 Linguagem: Inglês

10.1002/anie.200604364

1521-3773

Jongmin Park, Hyang Yeon Lee, Myung‐Haing Cho, Seung Bum Park,

Cancer, Hypoxia, and Metabolism

Tracing glucose uptake: Fluorescent glucose analogues were synthesized, and the importance of stereochemistry for cellular uptake efficiency was demonstrated. The chiral bioprobe 1 showed superior properties as a glucose-uptake tracer. The cellular uptake of 1 was demonstrated under various concentrations of D-glucose. A screening system was developed for the discovery of anticancer agents by the measurement of glucose uptake in cancer cells with 1. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604364_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.