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Daddy Issues: Paternal Effects on Phenotype

2012; Cell Press; Volume: 151; Issue: 4 Linguagem: Inglês

10.1016/j.cell.2012.10.020

1097-4172

Oliver J. Rando,

Genetics and Neurodevelopmental Disorders

The once popular and then heretical idea that ancestral environment can affect the phenotype of future generations is coming back into vogue due to advances in the field of epigenetic inheritance. How paternal environmental conditions influence the phenotype of progeny is now a tractable question, and researchers are exploring potential mechanisms underlying such effects. The once popular and then heretical idea that ancestral environment can affect the phenotype of future generations is coming back into vogue due to advances in the field of epigenetic inheritance. How paternal environmental conditions influence the phenotype of progeny is now a tractable question, and researchers are exploring potential mechanisms underlying such effects.