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A Selective Fluorescent Probe for Carbon Monoxide Imaging in Living Cells

2012; Wiley; Volume: 51; Issue: 38 Linguagem: Inglês

10.1002/anie.201203684

1521-3773

Jing Wang, Jason Karpus, Boxuan Zhao, Zheng Luo, Peng R. Chen, Chuan He,

Neuroscience of respiration and sleep

A genetically encoded fluorescent probe is capable of selectively detecting carbon monoxide inside living cell. The probe, named COSer (CO sensor), consists of a circularly permuted yellow fluorescent protein (cpYFP) inserted into the regulatory domain of the bacterial CO-sensing protein, CooA, which gives the probe its selective CO-binding property. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.