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Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture)

2009; Wiley; Volume: 48; Issue: 31 Linguagem: Inglês

10.1002/anie.200901916

ISSN

1521-3773

Autores

Roger Y. Tsien,

Tópico(s)

Advanced Biosensing Techniques and Applications

Resumo

Angewandte Chemie International EditionVolume 48, Issue 31 p. 5612-5626 Review Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture)† Roger Y. Tsien Prof., Roger Y. Tsien Prof. [email protected] Howard Hughes Medical Institute and Departments of Pharmacology and Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0647 (USA)Search for more papers by this author Roger Y. Tsien Prof., Roger Y. Tsien Prof. [email protected] Howard Hughes Medical Institute and Departments of Pharmacology and Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0647 (USA)Search for more papers by this author First published: 15 July 2009 https://doi.org/10.1002/anie.200901916Citations: 355 † Copyright© The Nobel Foundation 2008. We thank the Nobel Foundation, Stockholm, for permission to print this lecture. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Trip the light fantastic: The green fluorescent protein (GFP) is an invaluable tool for biochemical and medicinal research. It can make tumors, amyloid plaques from Alzheimer′s disease, or pathogenic bacteria equally visible. Ground-breaking contributions in this field have resulted in the 2008 Nobel Prize for Chemistry being awarded to Osamu Shimomura, Martin Chalfie, and Roger Tsien. The Nobel Laureates describe their research first-hand. 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