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Tumor/Stromal Caveolin-1 Expression Patterns in Pleural Mesothelioma Define a Subgroup of the Epithelial Histotype With Poorer Prognosis

2014; Oxford University Press; Volume: 141; Issue: 6 Linguagem: Inglês

10.1309/ajcp0f6wybxgvdhx

1943-7722

Luisella Righi, Maria Cristina Cavallo, G. Gatti, Valentina Monica, Ida Rapa, Simone Busso, Carlo Albera, Marco Volante, Giorgio V. Scagliotti, Mauro Papotti,

Occupational and environmental lung diseases

Malignant pleural mesothelioma (MPM) is a highly aggressive disease for which new prognostic biomarkers need to be identified. Caveolin-1 (CAV1), the most important member of caveolae, has been described as deregulated in MPM at the genomic level, but detailed histologic information on its distribution and prognostic role is still lacking.A series of 131 MPMs (91 epithelial, 17 biphasic, and 23 sarcomatous histotype) were investigated for CAV1 expression with immunohistochemistry and correlated with clinical-pathologic variables and outcome.CAV1 was detected in neoplastic cells of 70 (77%) of 91 epithelial, 17 (100%) of 17 biphasic, and 23 (100%) of 23 sarcomatous MPMs. Furthermore, in the epithelial group, CAV1 expression in spindle-shaped stromal cells was detected in 61 (67%) of 91 cases.The presence of stromal CAV1 expression was associated with a worse patient outcome. In MPM, CAV1 is differentially expressed according to low- to high-grade histotypes. Furthermore, in the MPM epithelial group, additional stromal CAV1 expression is associated with a worse prognosis.