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Normalization of FoxP3+ Regulatory T Cells in Response to Effective Antiretroviral Therapy

2010; Oxford University Press; Volume: 203; Issue: 4 Linguagem: Inglês

10.1093/infdis/jiq073

1537-6613

Martín Montes, César Sánchez, Dorothy E. Lewis, Edward A. Graviss, Carlos Seas, Eduardo Gotuzzo, A. Clinton White,

T-cell and B-cell Immunology

Regulatory T cells (Tregs) blunt uncontrolled immune responses. In advanced human immunodeficiency virus (HIV) infection, the total number of Tregs is decreased, but the proportion of T cells with a regulatory phenotype is highly variable. We studied CD4(+)CD25(+)FoxP3(+) T cells from patients successfully treated with combination antiretroviral therapy (ART). The proportion of CD4(+)CD25(+)FoxP3(+) cells transiently increased and then decreased from a median of 13% at baseline to 5.1% at 48 weeks, similar to values in normal subjects. These data suggest that with effective therapy, the regulatory cell numbers normalize, and that the inflammatory signals driving their production may also abate.