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Oral mucosal dendritic cells and periodontitis: many sides of the same coin with new twists

2007; Wiley; Volume: 45; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0757.2007.00222.x

1600-0757

Christopher W. Cutler, Yen-Tung A Teng,

Immunotherapy and Immune Responses

Periodontology 2000Volume 45, Issue 1 p. 35-50 Oral mucosal dendritic cells and periodontitis: many sides of the same coin with new twists Christopher W. Cutler, Christopher W. CutlerSearch for more papers by this authorYen-Tung A. Teng, Yen-Tung A. TengSearch for more papers by this author Christopher W. Cutler, Christopher W. CutlerSearch for more papers by this authorYen-Tung A. Teng, Yen-Tung A. TengSearch for more papers by this author First published: 10 September 2007 https://doi.org/10.1111/j.1600-0757.2007.00222.xCitations: 43Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 2005: 43: 5721–5732. 2 Akira S, Takeda K. Toll-like receptor signaling. Nat Rev Immunol 2004: 4: 499–511. 3 Al-Darmaki S, Knightshead K, Ishihara Y, Best A, Schenkein HA, Tew JG, Barbour SE. Delineation of the role of platelet-activating factor in the immunoglobulin G2 antibody response. Clin Diagn Lab Immunol 2004: 11: 720–728. 4 Al-Darmaki S, Schenkein HA, Tew JG, Barbour SE. Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells. J Immunol 2003: 170: 167–173. 5 Alnaeeli M, Penninger JM, Teng Y-T A. Immune interactions with CD4+ T-cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol 2006: 177: 3314–3326. 6 Amanuma R, Nakajima T, Yoshie H, Yamazaki K. Increased infiltration of CD1d+ and natural killer T cells in periodontal disease tissues. J Periodontal Res 2006: 41: 73–79. 7 Anderson DM, Maraskovsky E, Billingsley WL, Dougall W, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 1997: 390: 175–179. 8 Ardavin C. Origin, precursors and differentiation of mouse dendritic cells. Nat Rev Immunol 2003: 3: 582–590. 9 Bachmann MF, Wong BR, Josien R, Steinman RM, Oxenius A, Choi Y. TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J Exp Med 1999: 189: 1025–1031. 10 Bailey M, Haverson K. The postnatal development of the mucosal immune system and mucosal tolerance in domestic animals. Vet Res 2006: 37: 443–453. 11 Baker PJ. The role of immune responses in bone loss during periodontal disease. Microbes Infect 2000: 2: 1181–1192. 12 Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC. CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 1999: 67: 2804–2809. 13 Barbour SE, Ishihara Y, Fakher M, Al-Darmaki S, Caven TH, Shelburne CP, Best AM, Schenkein HA, Tew JG. Monocyte differentiation in localized juvenile periodontitis is skewed toward the dendritic cell phenotype. Infect Immun 2002: 7: 2780–2786. 14 Baumgartner DC, Metzke D, Schmitz J, Scheffold A, Sturm A, Wiedenmann B, Dignass AU. Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells. Gut 2005: 54: 228–236. 15 Brown GD, Herre J, Williams DL, Willment JA, Marshall AS, Gordon S. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 2003: 197: 1119–1124.pp. 16 Brown JM, Zhang J, Keller ET. OPG, RANKL and RANK in cancer metastasis: expression and regulation. Cancer Treat Res 2004: 118: 149–172. 17 Campbell JJ, Butcher EC. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 2000: 12: 336–341. 18 Caparros E, Munoz P, Sierra-Filardi E, Serrano-Gomez D, Puig-Kroger A, Rodriguez-Fernandez JL, Mellado M, Sancho J, Zubiaur M, Corbi AL. DC-SIGN ligation on dendritic cells results in ERK and PI3 K activation and modulates cytokine production. Blood 2006: 107: 3950–3958.Epub 24 January 2006. 19 Cavanagh LL, Von Andrian UH. Travellers in many guises: the origins and destinations of dendritic cells. Immunol Cell Biol 2002: 80: 448–462. 20 Champagne E, Martinez LO, Vantourout P, Collet X, Barbaras R. Role of apolipoproteins in gammadelta and NKT cell-mediated innate immunity. Immunol Res 2005: 33: 241–255. 21 Charbonnier AS, Kohrgruber N, Kriehuber E, Stingl G, Rot A, Maurer D. Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. J Exp Med 1999: 190: 1755–1768. 22 Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, Monti P, Piemonti L, Biondi A, Mantovani A, Introna M, Allavena P. Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. J Immunol 2003: 171: 4552–4560. 23 Chomarat P, Dantin C, Bennett L, Banchereau J, Palucka AK. TNF skews monocyte differentiation from macrophages to dendritic cells. J Immunol 2003: 171: 2262–2269. 24 Cirrincione C, Pimpinelli N, Orlando L, Romagnoli P. Lamina propria dendritic cells express activation markers and contact lymphocytes in chronic periodontitis. J Periodontol 2002: 73: 45–52. 25 Cohen N, Morisset J, Emilie D. Induction of tolerance by Porphyromonas gingivalis on APCS: a mechanism implicated in periodontal infection. J Dent Res 2004: 83: 429–433. 26 Cook GS, Costerton JW, Lamont RJ. Biofilm formation by Porphyromonas gingivalis and Streptococcus gordonii. J Periodontal Res 1998: 33: 323–327. 27 Cook DN, Prosser DM, Foster R, Zhang J, Kuklin NA, Abbondanzo SJ, Niu XD, Chen SC, Manfra DJ, Wiekowski MT, Sullivan LM, Smith SR, Greenberg HB, Narula SK, Lipp M, Lira SA. CCR6 mediates dendritic cell localization, lymphocyte homeostasis and immune responses in mucosal tissue. Immunity 2000: 12: 495. 28 Cutler CW, Jotwani R. Antigen-presentation and dendritic cells in periodontitis. Periodontol 2000 2004: 35: 135–157. 29 Cutler CW, Jotwani R. Dendritic cells at the oral mucosal interface. Crit Rev Oral Biol Med J Dent Res 2006: 85: 678–689. 30 Cutler CW, Jotwani R, Palucka KA, Davoust J, Bell D, Banchereau J. Evidence and a novel hypothesis for the role of dendritic cells and Porphyromonas gingivalis in adult periodontitis. J Periodontal Res 1999: 34: 406–412. 31 Da Costa C, Annels NE, Faaji CMJM, Forsyth RG, Hogendoorn PCW, Egeler RM. Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhan’s cell histiocytosis. J Exp Med 2005: 201: 687–693. 32 Delneste Y, Charbonnier P, Herbult N, Magistrell G, Caron G, Bonnefoy J-Y, Jeamin P. Interferon-γ switches monocyte differentiation from dendritic cells to macrophages. Blood 2003: 101: 143–150. 33 Dereka XE, Tosios KI, Chrysomali E, Angelopoulou E. Factor XIIIa + dendritic cells and S-100 protein + Langerhans’ cells in adult periodontitis. J Periodontal Res 2004: 39: 447–452. 34 Dieu M-C, Vanbervliet B, Vicari A, Bridon J-M, Oldham E, Ait-Yahia S, Briere F, Zlotnik S, Lebecque S, Caux C. Selective recruitment of immature and mature dendritic cell by distinct chemokines in distinct anatomic sites. J Exp Med 1998: 188: 373. 35 Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, Daro E, Smith J, Tometsko ME, Maliszewski CR, Armstrong A, Shen V, Bain S, Cosman D, Anderson D, Morrissey PJ, Peschon JJ, Schuh J. RANK is essential for osteoclast and lymph node development. Genes Dev 1999: 18: 2412–2424. 36 Eriksson K, Ahlfors E, George-Chandy A, Kaiserlian D, Czerkinsky C. Antigen presentation in the murine oral epithelium. Immunology 1996: 88: 147–152. 37 Feuerer M, Beckhove P, Garbi N, Mahnke Y, Limmer A, Hommel M, Hammerling GJ, Kyewski B, Hamann A, Umansky V, Schirrmacher V. Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Immunol 2003: 9: 1151–1157. 38 Figdor CG, Van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol 2002: 2: 77–84. 39 Föster R, Schubel A, Brietfeld D, Kremmer E, Renner-Müller I, Wolf E, Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999: 99: 23. 40 Fujimura Y. Evidence of M cells as portals of entry for antigens in the nasopharyngeal lymphoid tissue of humans. Virchows Arch 2000: 436: 560–566. 41 Fujimura Y, Takeda M, Ikai H, Haruma K, Akisada T, Harada T, Sakai T, Ohuchi M. The role of M cells of human nasopharyngeal lymphoid tissue in influenza virus sampling. Virchows Arch 2004: 444: 36–42. 42 Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of inflammatory responses by Dectin-1 and Toll-like receptor 2. J Exp Med 2003: 197: 1107–1117. 43 Garlet GP, Martins W Jr, Ferreira BR, Milanezi CM, Silva JS. Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. J Periodontal Res 2003: 38: 210–217. 44 Geijtenbeek TB, Van Vliet SJ, Engering A, ‘t Hart BA, Van Kooyk Y. Self- and nonself-recognition by C-type lectins on dendritic cells. Annu Rev Immunol 2004: 22: 33–54. 45 Gemmell E, Carter CL, Hart DN, Drysdale KE, Seymour GJ. Antigen-presenting cells in human periodontal disease tissues. Oral Microbiol Immunol 2002: 17: 388–393. 46 Gemmell E, Seymour GJ. Gamma delta T lymphocytes in human periodontal disease tissue. J Periodontol 1995: 66: 780–785. 47 Gemmell E, Yamazaki K, Seymour GJ. Destructive periodontitis lesions are determined by the nature of the lymphocytic response.Crit. Rev Oral Biol Med 2002: 13: 17–34. 48 Girardin SE, Philpott DJ. Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immunol 2004: 34: 1777–1782. 49 Girardin SE, Travassos LH, Herve M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003: 278: 41702–41708. 50 Grainger DJ, Reckless J. Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo. Biochem Pharmacol 2003: 65: 1027–1034. 51 Hasegawa T, Yoshimura Y, Kikuiri T, Yawaka Y, Takeyama S, Matsumoto A, Oguchi H, Shirakawa T. Expression of receptor activator of NF-kappa B ligand and osteoprotegerin in culture of human periodontal ligament cells. J Periodontal Res 2002: 37: 405–411. 52 Highton J, Kean A, Hessian PA, Thomson J, Rietveld J, Hart DN. Cells expressing dendritic cell markers are present in the rheumatoid nodule. J Rheumatol 2000: 27: 339–346. 53 Hirata H, Arima M, Cheng G, Honda K, Fukushima F, Yoshida N, Eda F, Fukuda T. Production of TARC and MDC by naive T cells in asthmatic patients. J Clin Immunol 2003: 23: 34–45. 54 Hofbauer LC, Schoppet M. Clinical implication of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases. JAMA 2004: 28: 490–495. 55 Honore P, Luger NM, Sabino MAC, Schwei MJ, Rogers SD, Mach DB. Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med 2000: 6: 521–528. 56 Hosokawa Y, Nakanishi T, Yamaguchi D, Takahashi K, Yumoto H, Ozaki K, Matsuo T. Macrophage inflammatory protein 3alpha-CC chemokine receptor 6 interactions play an important role in CD4+ T-cell accumulation in periodontal diseased tissue. Clin Exp Immunol 2002: 128: 548–554. 57 Hume DA. The mononuclear phagocyte system. Curr Opin Immunol 2006: 18: 49–53. 58 Imamura T, Travis J, Potempa J. The biphasic virulence activities of gingipains: activation and inactivation of host proteins. Curr Protein Pept Sci 2003: 4: 443–450. 59 Iwasaki A. Kelsall BL Localization of distinct Peyer’s patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. J Exp Med 2000: 191: 1381–1394. 60 James SP. Prototypic disorders of gastrointestinal mucosal immune function: celiac disease and Crohn’s disease. J Allergy Clin Immunol 2005: 115: 25–30. 61 Janeway CA, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002: 20: 197–216.pp. 62 Jotwani R, Cutler CW. Multiple dendritic cell (DC) subpopulations in human gingiva and association of mature DC with CD4+ T-cells in situ. J Dent Res 2003: 82: 736–741. 63 Jotwani R, Cutler CW. Fimbriated Porphyromonas gingivalis is more efficient than fimbria-deficient P. gingivalis in entering human dendritic cells in vitro and induces an inflammatory Th1 effector response. Infect Immun 2004: 72: 1725–1732. 64 Jotwani R, Muthukuru M, Cutler CW. Increase in HIV receptors/co-receptors/α-defensins in inflamed human gingiva. J Dent Res 2004: 83: 371–378. 65 Jotwani R, Palucka AK, Al-Quotub M, Kim J, Bell D, Banchereau J, Cutler CW. Dendritic cells infiltrate T-cell rich oral mucosa in chronic periodontitis: in situ, in vivo and in vitro studies. J Immunol 2001: 167: 4693–4700. 66 Jotwani R, Pulendran B, Agrawal S, Cutler CW. Human dendritic cells respond to Porphyromonas gingivalis LPS by promoting TH2 effector response in vitro. Eur J Immunol 2003: 33: 2980–2986. 67 Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, Liu YJ. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001: 194: 863–869. 68 Kantarci A, Van Dyke TE. Resolution of inflammation in periodontitis. J Periodontol 2005: 76(Suppl.): 2168–2174. 69 Kawai T, Eisen-Lev R, Seki M, Eastcott JW, Wilson ME, Taubman MA. Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. J Immunol 2000: 164: 2102–2109. 70 Kawasaki S, Matsushima K. Chemokines and chemokine receptors in collagen diseases. Nippon Rinsho 1999: 57: 278–282. 71 Kesavalu L, Holt SC, Ebersole JL. In vitro environmental regulation of Porphyromonas gingivalis growth and virulence. Oral Microbiol Immunol 2003: 18: 226–233. 72 Kikuchi T, Hahn CL, Tanaka S, Barbour SE, Schenkein HA, Tew JG. Dendritic cells stimulated with Actinobacillus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells. Infect Immun 2004: 72: 5089–5096. 73 Kikuchi T, Willis DL, Liu M, Purkall DB, Sukumar S, Barbour SE, Schenkein HA, Tew JG. Dendritic-natural killer cell interactions in P. gingivalis-specific responses. J Dent Res 2005: 84: 858–862. 74 Kinane DF, Demuth DR, Gorr SU, Hajishengallis G, Martin M. Human variability in innate immunity. Periodontol 2000 2007: 45: 14–34. 75 Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 1999: 402: 304–308. 76 Van Kooyk Y, Engering A, Lekkerkerker AN, Ludwig IS, Geijtenbeek TB. Pathogens use carbohydrates to escape immunity induced by dendritic cells. Curr Opin Immunol 2004: 16: 488–493. 77 Van Kooyk Y, Geijtenbeek TB. DC-SIGN: escape mechanism for pathogens. Nat Rev Immunol 2003: 3: 697–709. 78 Kunisawa J, Fukuyama S, Kiyono H. Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr Mol Med 2005: 5: 557–572. 79 Lacey DL, Timms E, Tan HL, Kelly MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998: 93: 165–176. 80 Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000: 106: 1481–1488. 81 Lean JM, Fuller K, Chambers T. FLT3-ligand can substitute for macrophage colony-stimulating factor in support of osteoclast differentiation and function. Blood 2001: 98: 2707–2713. 82 Leon B, Martinez del Hoyo G, Parrillas V, Vargas HH, Sanchez-Mateos P, Longo N, Lopez-Bravo M, Ardavin C. Dendritic cell differentiation potential of mouse monocytes: monocytes represent immediate precursors of CD8− and CD8+ splenic dendritic cells. Blood 2004: 103: 2668–2676. 83 Leung BP, Xu D, Culshaw S, McInnes IB, Liew FY. A novel therapy of murine collagen-induced arthritis with soluble T1/ST2. J Immunol 2004: 173: 145–150. 84 Lindsay JO, Whelan K, Stagg AJ, Gobin P, Al-Hassi HO, Rayment N, Kamm MA, Knight SC, Forbes A. Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn’s disease. Gut 2006: 55: 348–355. 85 Loos BG, Dyer DW, Whittam TS, Selander RK. Genetic structure of populations of Porphyromonas gingivalis associated with periodontitis and other oral infections. Infect Immun 1993: 61: 204–212. 86 Lundqvist C, Hammarstrom S, Hammarstrom ML. Intraepithelial lymphocytes expressing TCR gamma delta in human gingival tissues. Adv Exp Med Biol 1995: 371B: 1097–1102. 87 MacDonald KP, Pettit AR, Quinn C, Thomas GJ, Thomas R. Resistance of rheumatoid synovial dendritic cells to the immunosuppressive effects of interleukin-10. J Immunol 1999: 163: 5599–5607. 88 MacDonald KPA, Rowe V, Bofinger HM, Thomas R, Sasmono T, Hume DA, Hill GR. The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. J Immunol 2005: 175: 1399–1405. 89 Mahamed D, Marleau A, Alnaeeli M, Singh B, Zhang X, Penninger JM, Teng Y-TA. G(–) anaerobe-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes 2005: 54: 1477–1486. 90 Mahanonda R, Sa-Ard-Iam N, Yongvanitchit K, Wisetchang M, Ishikawa I, Nagasawa T, Walsh DS, Pichyangkul S. Upregulation of co-stimulatory molecule expression and dendritic cell marker (CD83) on B cells in periodontal disease. J Periodontal Res 2002: 37: 177–183. 91 McKenna HJ, Stocking KL, Miller RE, Brasel K, De Smedt T, Maraskovesky E, Maliszewski CR, Lynch DH, Smith J, Pulendran B, Roux ER, Teepe M, Lyman SD, Peschon JJ. Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 2000: 95: 3489–3497. 92 Menard C, Mouton C. Genetic structure of populations of Porphyromonas gingivalis associated with periodontitis and other oral infections. Infect Immun 1993: 61: 204–212. 93 Miyamoto T, Ohneda O, Arai F, Iwamoto K, Okada S, Takagi K, Anderson DM, Suda T. Bifurcation of osteoclasts and dendritic cells from common progenitors. Blood 2001: 98: 2544–2554. 94 Mizuno A, Amizuka N, Irie K, Murakami A, Fujise N, Kanno T et al. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun 1998: 247: 610–615. 95 Mojon P, Bureau J. Respiratory infection: how important is oral health? Curr Opin Pulm Med 2003: 9: 166–170. 96 Monteleone G, Fina D, Caruso R, Pallone F. New mediators of immunity and inflammation in inflammatory bowel disease. Curr Opin Gastroenterol 2006: 22: 361–364. 97 Mowat AM, Parker LA, Beacock-Sharp H, Millington OR, Chirdo F. Oral tolerance: overview and historical perspectives. Ann N Y Acad Sci 2004: 1029: 1–8. 98 Muller G, Hopken UE, Stein H, Lipp M. Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J Leukoc Biol 2002: 72: 1–8. 99 Muthukuru M, Cutler CW. Upregulation of immunoregulatory Src homology 2 molecule containing inositol phosphatase and mononuclear cell hyporesponsiveness in oral mucosa during chronic periodontitis. Infect Immun 2006: 74: 1431–1435. 100 Muthukuru M, Jotwani R, Cutler CW. Induction of oral mucosal endotoxin tolerance in chronic periodontitis. Infect Immun 2005: 73: 687–694. 101 Muzio M, Bosisio D, Polentarutti N, D’amico G, Stoppacciaro A, Mancinelli R, Van’t Veer C, Penton-Rol G, Ruco LP, Allavena P, Mantovani A. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol 2000: 164: 5998–6004. 102 Nagasawa T, Kobayashi H, Kiji M, Aramaki M, Mahanonda R, Kojima T et al. LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin. Clin Exp Immunol 2002: 130: 338–344. 103 Newberry RD, Lorenz RG. Organizing a mucosal defense. Immunol Rev 2005: 206: 6–21. 104 Niess JH, Reinecker HC. Dendritic cells: the commanders-in-chief of mucosal immune defenses. Curr Opin Gastroenterol 2006: 22: 354–360. 105 Nigou J, Zelle-Rieser C, Gilleron M, Thurnher M, Puzo G. Mannosylated lipoarabinomannans inhibit IL-12 production by human dendritic cells: evidence for a negative signal delivered through the mannose receptor. J Immunol 2001: 166: 7477–7485. 106 Nukaga J, Kobayashi M, Shinki T, Song H, Takada T, Takiguchi T, Kamijo R, Hasegawa K. Regulatory effects of interleukin-1beta and prostaglandin E2 on expression of receptor activator of nuclear factor-kappa B ligand in human periodontal ligament cells. J Periodontol 2004: 75: 249–259. 107 Okuda K, Kimizuka R, Abe S, Kato T, Ishihara K. Involvement of periodontopathic anaerobes in aspiration pneumonia. J Periodontol 2005: 76 (11 Suppl): 2154–2160. 108 Page G, Lebecque S, Miossec P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective expression in rheumatoid synovium. J Immunol 2002: 168: 5333–5341. 109 Page G, Miossec P. RANK and RANKL expression as markers of dendritic cell T cell interactions in paired samples of rheumatoid synovium and lymph nodes. Arthritis Rheum 2005: 52: 2307–2312. 110 Persing DH, Coler RN, Lacy MJ, Johnson DA, Baldridge JR, Hershberg RM, Reed SG. Taking toll: lipid A mimetics as adjuvants and immunomodulators. Trends Microbiol 2002 2002: 10: s32–s37. 111 Pulendran B, Kumar P, Cutler CW, Mohamadzadeh M, Van Dyke T, Banchereau J. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J Immunol 2001: 167: 5067–5076. 112 Rani CS, MacDougall M. Dental cells express factors that regulate bone resorption. Mol Cell Biol Res Commun 2000: 3: 145–152. 113 Relloso M, Puig-Kroger A, Pello OM, Rodriguez-Fernandez JL, De La Rosa G, Longo N, Navarro J, Munoz-Fernandez MA, Sanchez-Mateos P, Corbi AL. DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-beta, and anti-inflammatory agents. J Immunol 2002: 168: 2634–2643. 114 Rhee KJ, Sethupathi P, Driks A, Lanning DK, Knight KL. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J Immunol 2004: 172: 1118–1124. 115 Rivollier A, Mazzorana M, Tebib J, Piperno M, Aitsiselmi T, Rabourdin-Combe C, Jurdic P, Servet-Delprat C. Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by rheumatoid arthritis microenvironment. Blood 2004: 104: 4029–4037. 116 Rozell B, Ljungdahl PO, Martinez P. Host–pathogen interactions and the pathological consequences of acute systemic Candida albicans infections in mice. Curr Drug Targets 2006: 7: 483–494. 117 Saeki T, Naya A. CCR1 chemokine receptor antagonist. Curr Pharm Des 2003: 9: 1201–1208. 118 Santiago-Schwarz F, Anand P, Liu S, Carsons SE. Dendritic cells (DCs) in rheumatoid arthritis (RA): progenitor cells and soluble factors contained in RA synovial fluid yield a subset of myeloid DCs that preferentially activate Th1 inflammatory-type responses. J Immunol 2001: 67: 1758–1768. 119 Sasaki M, Hasegawa H, Kohno M, Inoue A, Ito MR, Fujita S. Antagonist of secondary lymphoid-tissue chemokine (CCR ligand 21) prevents the development of chronic graft-versus-host disease in mice. J Immunol 2003: 170: 588–596. 120 Schuler G, Lutz MB, Bender A, Thurner B, Röder C, Young J, Romani N. A guide to the isolation and propagation of dendritic cells. In: MT Lotze, AW Thomson, editors. Dendritic Cells: Biology and Clinical Applications Chapter 27. San Diego, CA: Academic, 1999: 27 pp. 121 Scimone ML, Lutzky VP, Zittermann SI, Maffia P, Jancic C, Buzzola F, Issekutz AC, Chuluyan HE. Migration of polymorphonuclear leucocytes is influenced by dendritic cells. Immunology 2005: 114: 375–385. 122 Serbina NV, Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol 2006: 7: 311–317. 123 Servet-Delprat C, Arnaud S, Jurdic P, Nataf S, Grasset MF, Soulas C, Domenget C, Destaing O, Rivollier A, Perret M, Dumontel C, Hanau D, Gilmore GL, Belin MF, Rabourdin-Combe C, Mouchiroud G. Flt3+ macrophage precursors commit sequentially to osteoclasts, dendritic cells and microglia. BMC Immunol 2002: 3: 15. 124 Shurin MR, Pandharipande PP, Zorina TD, Haluszczak C, Subbotin VM, Hunter O, Brumfield A, Storkus WJ, Maraskovsky E, Lotze MT. FLT3 ligand induces the generation of functionally active dendritic cells in mice. Cell Immunol 1997: 179: 174–184. 125 Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997: 89: 309–319. 126 Smits HH, Engering A, Van Der Kleij D, De Jong EC, Schipper K, Van Capel TM, Zaat BA, Yazdanbakhsh M, Wierenga EA, Van Kooyk Y, Kapsenberg ML. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 2005: 115: 1260–1267. 127 Spahn TW, Fontana A, Faria AM, Slavin AJ, Eugster HP, Zhang X, Koni PA, Ruddle NH, Flavell RA, Rennert PD, Weiner HL. Induction of oral tolerance to cellular immune responses in the absence of Peyer’s patches. Eur J Immunol 2001: 31: 1278–1287. 128 Stanley E, Lieschke GJ, Grail D, Metcalf D, Hodgson G, Gall JAM, Maher DW, Cebon J, Sinickas V, Dunn AR. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A 1994: 91: 5592–5596. 129 Steinman RM, Hawiger D, Liu K, Bonifaz L, Bonnyay D, Mahnke K, Iyoda T, Ravetch J, Dhodapkar M, Inaba K, Nussenzweig M. Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann N Y Acad Sci 2003: 987: 15–25. 130 Steinman R, Hoffman L, Pope M. Maturation and migration of cutaneous dendritic cells. J Invest Dermatol 1995: 105 (11 Suppl.): 2S–7S. 131 Tanaka S, Takahashi N, Udagawa N, Tamura T, Akatsu T, Stanley ER, Kurokawa T, Suda T. Macrophage colony stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest 1993: 91: 257–263. 132 Taubman MA, Kawai T. Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med 2001: 12: 125–135. 133 Teitelbaum SL, Ross FP. Genetic regulation of osteoclast development and function. Nat Rev Genet 2003: 8: 638–649. 134 Teng Y-TA. Mixed periodontal Th1/Th2 cytokines in Actinobacillus actinomycetemcomitans-specific osteoprotegerin ligand (or RANK-L)-mediated alveolar bone destruction in vivo. Infect Immun (Notes) 2002: 70: 5269–5273. 135 Teng Y-TA. The role of acquired immunity in periodontal disease progression. Crit Rev Oral Biol Med 2003: 14: 237–252. 136 Teng Y-TA. Protective and destructive immunity in the periodontium: (Part 1) – innate and humoral immunity and the periodontium. J Dent Res 2006: 85: 198–208. 137 Teng Y-TA. Protective and destructive immunity in the periodontium. Part 2: T-cell-mediated immunity in the periodontium. J Dent Res 2006: 85: 209–219. 138 Teng Y-TA, Mahamed D, Singh B. IFN-γ positively modulates Actinobacillus actinomycetemcomitans-specific CD4+ T cells-mediated alveolar bone destruction in vivo. Infect Immun 2005: 73: 3453–3461. 139 Teng YA, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, Ellen RP, Penninger JM. Functional human T-cell immunity and osteoprotegerin-ligand (OPG-L) control alveolar bone destruction in periodontal infection. J Clin Invest 2000: 106: R59–R67. 140 Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cell, bone loss and mammalian evolution. Annu Rev Immunol 2002: 20: 795–823. 141 Thomas R, MacDonald KP, Pettit AR, Cavanagh LL, Padmanabha J, Zehntner S. Dendritic cells and the pathogenesis of rheumatoid arthritis. J Leukoc Biol 1999: 66: 286–292. 142 Thoma-Uszynski S, Kiertscher SM, Ochoa MT, Bouis DA, Norgard MV, Miyake K, Godowski PJ, Roth MD, Modlin RL. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10. J Immunol 2000: 165: 3804–3810. 143 Tlaskalova-Hogenova H, Stepankova R, Hudcovic T, Tuckova L, Cukrowska B, Lodinova-Zadnikova R, Kozakova H, Rossmann P, Bartova J, Sokol D, Funda DP, Borovska D, Rehakova Z, Sinkora J, Hofman J, Drastich P, Kokesova A. Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol Lett 2004: 93: 97–108. 144 Tuite-McDonnell M, Griffen AL, Moeschberger ML, Dalton RE, Fuerst PA, Leys EJ. Concordance of Porphyromonas gingivalis colonization in families. J Clin Microbiol 1997: 35: 455–461. 145 Uehara A, Sugawara Y, Kurata S, Fujimoto Y, Fukase K, Kusumoto S, Satta Y, Sasano T, Sugawara S, Takada H. Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells. Cell Microbiol 2005: 7: 675–686. 146 Underhill DM, Ozinsky A. Toll-like receptors: key mediators of microbe detection. Curr Opin Immunol 2002: 14: 103–110 pp. 147 Upham JW, Stumbles PA. Why are dendritic cells important in allergic diseases of the respiratory tract? Pharmacol Ther 2003: 100: 75–87. 148 Valverde P, Kawai T, Taubman MA. Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease. J Bone Miner Res 2004: 19: 155–164. 149 Wong BR, Josien R, Lee SY, Sauter B, Li HL, Steinman RM, Choi Y. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 1997: 186: 2075–2080. 150 Wu HY, Nguyen HH, Russell MW. Nasal lymphoid tissue (NALT) as a mucosal immune inductive site. Scand J Immunol 1997: 46: 506–513. 151 Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T. et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 1998: 95: 3597–3602. 152 Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990: 345: 442–444. 153 Zhang X, Teng Y-TA. IL-10 inhibits G(–) microbe-specific RANKL + CD4+ Th1 cells-associated alveolar bone loss in vivo. Infect Immun (Notes) 2006: 74: 4927–4931. 154 Zuniga EI, McGavern DB, Pruneda-Paz JL, Teng C, Oldstone MBA. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nat Immunol 2004: 5: 1227–1234. Citing Literature Volume45, Issue1October 2007Pages 35-50 ReferencesRelatedInformation