THYROXINE ANALOGUES AND CHOLESTEROL METABOLISM: THE RELATIVE EFFECTS OF VARIOUS THYROXINE DERIVATIVES ON GROWTH, OXYGEN CONSUMPTION AND TISSUE CHOLESTEROL CONCENTRATIONS IN THE RAT
1960; Oxford University Press; Volume: 66; Issue: 2 Linguagem: Inglês
10.1210/endo-66-2-160
ISSN1945-7170
AutoresW. R. RUEGAMKR, Morton Alpert, F. R. SILVERMAN,
Tópico(s)Thyroid Disorders and Treatments
ResumoA number of thyroxinc analogues have been tested for their relative effects on tissue cholesterol concentrations, oxygen consumption, and growth in the hypercholesterolemic rat. Of the compounds studied, diiodothyroacetic (Diac) and diiodothyroformic acid (T2 FA) appear to have the greatest effect in reducing tissue cholesterol concentrations without affecting growth or basal metabolism. Other derivatives such as tri- and tetraiodothyroacetic acids, triiodothyropropionic acid and tetraiodothyroformic acid have been shown by others to exert some preferential effect on tissue cholesterol concentrations. However, when compared on an equal molar basis in the present study, these compounds were not nearly as effective as Diac and T2 FA in lowering cholesterol levels.
Referência(s)