Role of Porins in the Susceptibility of Mycobacterium smegmatis and Mycobacterium chelonae to Aldehyde-Based Disinfectants and Drugs
2009; American Society for Microbiology; Volume: 53; Issue: 9 Linguagem: Inglês
10.1128/aac.00590-09
ISSN1098-6596
AutoresZuzana Svetlíková, Henrieta Škovierová, Michael Niederweis, Jean‐Louis Gaillard, Gerald McDonnell, Mary Jackson,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoABSTRACT Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho -phthalaldehyde. Since defects in porin activity also dramatically increased the resistance of M. chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho -phthalaldehyde in clinical settings may select for drug-resistant bacteria.
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