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Aging skin is functionally anaerobic: Importance of coenzyme Q 10 for anti aging skin care

2008; Wiley; Volume: 32; Issue: 1-4 Linguagem: Inglês

10.1002/biof.5520320129

1872-8081

Stefanie Prahl, Thomas Kueper, T. Biernoth, Y. Wöhrmann, Andrew M. Munster, Manuela Fürstenau, Melanie Schmidt, Christian Schulze, K. P. Wittern, Horst Wenck, Gesa‐Meike Muhr, Thomas Blatt,

Biochemical effects in animals

The functional loss of mitochondria represents an inherent part in modern theories trying to explain the cutaneous aging process. The present study shows significant age-dependent differences in mitochondrial function of keratinocytes isolated from skin biopsies of young and old donors. Our data let us postulate that energy metabolism shifts to a predominantly non-mitochondrial pathway and is therefore functionally anaerobic with advancing age. CoQ10 positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo.