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Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves of Croton campestris A. St.-Hill in Rodents

2013; Hindawi Publishing Corporation; Volume: 2013; Linguagem: Inglês

10.1155/2013/579346

1741-4288

Francisco Elizaudo de Brito, Dayanne Rakelly de Oliveira, Elizângela Beneval Bento, Laura Hévila Inocêncio Leite, Daniele Oliveira Souza, Ana Luiza Albuquerque Siebra, Renata Souza Sampaio, Anita Oliveira Pereira Bezerra Brito Martins, Andreza Guedes Barbosa Ramos, Saulo Relison Tintino, Luiz Jardelino de Lacerda Neto, Patrícia Rosane Leite de Figueiredo, Larissa Rolim de Oliveira, Cristina K. S. Rodrigues, Valterlucio Santos Sales, Francisco R. S. D. N. Figueiredo, Emmily Petícia do Nascimento, Álefe Brito Monteiro, Érika N. Amaro, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf,

Phytochemistry and Bioactive Compounds

Croton campestris A. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found that C. campestris represents a promising natural source with important biological potential, justifying some of its uses in folk medicine.