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Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis

2011; Public Library of Science; Volume: 9; Issue: 3 Linguagem: Inglês

10.1371/journal.pbio.1000598

1545-7885

Mathieu Blanc, Wei Yuan Hsieh, Kevin A. Robertson, Steven Watterson, Guanghou Shui, Paul Lacaze, Mizanur Khondoker, Paul Dickinson, Garwin Sing, Sara Rodríguez‐Martín, Peter E. Phelan, Thorsten Forster, Birgit Strobl, Mathias Müller, Rudolph A. Riemersma, Timothy F. Osborne, Markus R. Wenk, Ana Angulo, Peter Ghazal,

Systemic Lupus Erythematosus Research

Upon infection, our immune cells produce a small protein called interferon, which in turn signals a protective response through a series of biochemical reactions that involves lowering the cells' ability to make cholesterol by targeting a gene essential for controlling the pathway for cholesterol metabolism.