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Bioactivity studies on Musa seminifera Lour

2013; SAGE Publishing; Volume: 9; Issue: 36 Linguagem: Inglês

10.4103/0973-1296.117827

0976-4062

SatyajitD Sarker, Himangsu Mondal, Royhan Gofur, Md Morsaline Billah, Lutfun Nahar, Sanjib Saha, Jamil A. Shilpi,

Phytochemistry and Bioactivity Studies

Pharmacognosy Magazine,2013,9,36, 315-322.DOI:10.4103/0973-1296.117827Published:September 2013Type:Original ArticleAuthors:Sanjib Saha, Jamil A Shilpi, Himangsu Mondal, Royhan Gofur, Morsaline Billah, Lutfun Nahar, and Satyajit D Sarker Author(s) affiliations:Sanjib Saha1, Jamil A Shilpi1, Himangsu Mondal1, Royhan Gofur2, Morsaline Billah3, Lutfun Nahar4, Satyajit D Sarker5 1Pharmacy Discipline, Khulna University, Khulna 9208, Bangladesh 2Department of Animal Husbandry and Veterinary Science, Rajshahi University, Rajshahi 6205, Bangladesh 3Department of Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh 4Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, United Kingdom 5Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, Wolverhampton WV1 1LY, West Midlands, United Kingdom Abstract:Background: Musa seminifera Lour is a tree-like perennial herb that has been used in folk medicine in Bangladesh to heal a number of ailments. Objective: To evaluate the antioxidant, analgesic, antidiarrheal, anthelmintic activities, and general toxicity of the ethanol extract of the roots. Materials and Methods: The extract was assessed for free-radical-scavenging activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, total phenolic content (TPC) by the Folin Ciocalteu reagent, antioxidant activity by the ferric reducing power assay, analgesic activity by the acetic acid-induced writhing and hot-plate tests, antidiarrheal activity by the castor oil-induced diarrhea model in mice, anthelmintic activity on Paramphistomum cervi and Haemonchus contortus, and general toxicity by the brine shrimp lethality assay. Results: The extract showed free-radical-scavenging activity with an IC 50 value of 44.86 μg/mL. TPC was 537.89 mg gallic acid equivalent/100 g of dried plant material. It showed concentration-dependent reducing power, and displayed 42.11 and 69.32% writhing inhibition at doses of 250 and 500 mg/kg body weight, respectively. The extract also significantly raised the pain threshold at the above-mentioned dose levels. In vivo antidiarrheal property was substantiated by significant prolongation of latent period and decrease in total number of stools compared with the control. The LC 50 against brine shrimp nauplii was 36.21 μg/mL. The extract exhibited dose-dependent decrease in paralysis and death time of the helminths. Conclusion: The above results demonstrated that the plant possesses notable bioactivities and somewhat supports its use in folk medicine. Keywords:2, 2-diphenyl-1-picrylhydrazyl, analgesic activity, Anthelmintic activity, Brine shrimp lethality, Folin Ciocalteu′s reagent, reducing powerView:PDF (913.5 KB) Full Text