Second Derivative Spectrophotometric Determination of p-Aminophenol in the Presence of Paracetamol
1991; Taylor & Francis; Volume: 24; Issue: 1 Linguagem: Inglês
10.1080/00032719108052889
ISSN1532-236X
AutoresAkgül Yeşilada, Hakkı Erdoğan, Mevlüt Ertan,
Tópico(s)Analytical Chemistry and Sensors
ResumoAbstract A second derivative spectroscopic method for the determination of p-aminophenol in paracetamol powder is described. Second derivative absorbance (d2A/dλ2) values were measured at 223.8 nm (Δ = 4.2 nm) where p-aminophenol showed derivative responses obeying Beer's Law but paracetamol had negligible derivative absorption. The concentrations of p-aminophenol solutions prepared in 0.1 N HCl (0.12–7.61 mcg/ml), containing constant amounts of paracetamol (20 mcg/ml) related linearly with the d2A/dλ2 values and gave a straight line (r = −0.9999). The method allowed determination of 0.5% to 38% of p-aminophenol in paracetamol without prior separation, it is rapid, precise and accurate. Key Words: Paracetamolp-aminophenolsecond derivative spectroscopy
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