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Comparison of Fecal Elastase-1 Determination with the Secretin-Cholecystokinin Test in Patients with Cystic Fibrosis

1999; Taylor & Francis; Volume: 34; Issue: 2 Linguagem: Inglês

10.1080/00365529950173104

1502-7708

Jarosław Walkowiak, Wojciech Cichy, Karl‐Heinz Herzig,

Pancreatic and Hepatic Oncology Research

AbstractBackground: The secretin-cholecystokinin (CCK) test is the gold standard in the evaluation of exocrine pancreatic insufficiency. Because of its invasive character, it is of limited value in cystic fibrosis (CF) patients, especially in those with severe respiratory disease. The aim of the study was to evaluate the sensitivity of fecal elastase-1 in relation to the secretin-CCK test and quantitative fecal fat excretion in CF patients. Methods: The study comprised 28 patients (11 females and 17 males) aged 4 to 20 years. In all patients the secretin-CCK test and determination of fecal elastase-1 concentration (with enzyme-linked immunosorbent assay) and fecal fat excretion were performed. Results