Evaluation of catalytic activity of copper salts and their removal processes in the three-component coupling reactions
2008; International Union of Pure and Applied Chemistry; Volume: 80; Issue: 5 Linguagem: Inglês
10.1351/pac200880050873
ISSN1365-3075
AutoresSeung Jun Hwang, Seung Hwan Cho, Sukbok Chang,
Tópico(s)Chemical Synthesis and Analysis
ResumoAbstract The catalytic activity of a wide range of copper salts, including Cu(I) and Cu(II), has been examined in the Cu-catalyzed three-component coupling reactions of sulfonyl azides, terminal alkynes, and amines, alcohols, or water to afford N -sulfonyl amidines, imidates, and amides, respectively. Furthermore, the investigation on the ligand effect in our protocol has revealed that certain types of ligands such as tris(benzyltriazolylmethyl)amine (TBTA) exhibited notable acceleration effects on the coupling reaction. The facile and efficient methods for removing copper salts from reaction mixture were also examined.
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