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SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases

2015; American Chemical Society; Volume: 11; Issue: 3 Linguagem: Inglês

10.1021/acschembio.5b00812

1554-8937

Jing Zhang, Y. George Zheng,

RNA modifications and cancer

S-Adenosyl-L-methionine (SAM) is a sulfonium molecule with a structural hybrid of methionine and adenosine. As the second largest cofactor in the human body, its major function is to serve as methyl donor for SAM-dependent methyltransferases (MTases). The resultant transmethylation of biomolecules constitutes a significant biochemical mechanism in epigenetic regulation, cellular signaling, and metabolite degradation. Recently, numerous SAM analogs have been developed as synthetic cofactors to transfer the activated groups on MTase substrates for downstream ligation and identification. Meanwhile, new compounds built upon or derived from the SAM scaffold have been designed and tested as selective inhibitors for important MTase targets. Here, we summarized the recent development and application of SAM analogs as chemical biology tools for MTases.