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EFFECTIVENESS OF EARLY INITIATION OF PROTEASE INHIBITOR-SPARING ANTIRETROVIRAL REGIMEN IN HUMAN IMMUNODEFICIENCY VIRUS-1 VERTICALLY INFECTED INFANTS

2007; Lippincott Williams & Wilkins; Volume: 26; Issue: 4 Linguagem: Inglês

10.1097/01.inf.0000258626.34984.eb

1532-0987

Dimitri Van der Linden, Marc Hainaut, Tessa Goetghebuer, Edwige Haelterman, Véronique Schmitz, Philip Maes, Alexandra Peltier, Jack Lévy,

HIV/AIDS drug development and treatment

Each of the 17 vertically infected infants born to HIV-1-infected mothers in Belgian HIV reference centers since 1996 was treated with a combination of 3 reverse transcription inhibitors as soon as the diagnosis was established. Treatment was initiated in all patients before 66 days of life. Twelve patients, including 11/13 infants treated with the combination of zidovudine, lamivudine and nevirapine, experienced a complete viral suppression (<50 copies/mL) with their first drug regimen. At last follow-up, 12 patients were asymptomatic, 2 were CDC stage A and 3 were stage B; 15 had HIV-1 RNA levels of or=25% CD4 lymphocytes. These results suggest that early initiation of treatment with 3 reverse transcription inhibitors is highly effective to inhibit viral replication and to prevent clinical and immunologic progression of HIV infection in vertically infected infants.