Malaria Hidden in a Patient with Diffuse Large-B-Cell Lymphoma and Sickle-Cell Trait
2011; American Society for Microbiology; Volume: 49; Issue: 12 Linguagem: Inglês
10.1128/jcm.00911-11
ISSN1098-660X
AutoresMaría Linares, Enriqueta Albízua, Darío Méndez, José Miguel Rubio, Alejandra Martínez-Serna, Miguel Ángel Martínez, Efrén Salto, Antonio Puyet, Amalia Díez, Joaquín Martínez‐López, José M. Bautista,
Tópico(s)Vector-borne infectious diseases
ResumoABSTRACT We report a case of an African patient with sickle cell trait who was diagnosed in Spain with B-cell lymphoma. Blood smears were negative for malaria, and no plasmodium antigens were detected in the blood. To treat his lymphoma, the patient underwent chemotherapy and autologous stem cell transplantation. Following a splenectomy due to a worsening condition, he developed clinical malaria with detectable parasitemia. This case suggests that the humoral response and parasite removal by the spleen may afford protection from overt disease and may even help maintain subclinical human reservoirs of the disease.
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