Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

The Furin Inhibitor Hexa- d -Arginine Blocks the Activation of Pseudomonas aeruginosa Exotoxin A In Vivo

2002; American Society for Microbiology; Volume: 70; Issue: 12 Linguagem: Inglês

10.1128/iai.70.12.7136-7139.2002

ISSN

1098-5522

Autores

Miroslav S. Sarač, Angus Cameron, Iris Lindberg,

Tópico(s)

Microbial infections and disease research

Resumo

ABSTRACT The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable furin inhibitor hexa- d -arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa- d -arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.

Referência(s)