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Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease

2002; Elsevier BV; Volume: 89; Issue: 7 Linguagem: Inglês

10.1016/s0002-9149(02)02202-6

1879-1913

Seok‐Min Kang, Yangsoo Jang, J.i-Young Kim, Namsik Chung, Seung-Yun Cho, Jey Sook Chae, Jong-H.o Lee,

Pharmacology and Obesity Treatment

High androgen levels in men have been regarded as a risk factor for coronary artery disease (CAD). 1 Lerner D.J. Kannel W.B. Patterns of coronary heart disease morbidity and mortality in the sexes a 26-year follow-up of the Framingham population. Am Heart J. 1986; 111: 383-390 Abstract Full Text PDF PubMed Scopus (1477) Google Scholar However, it has recently been demonstrated that supplements of androgens inhibit atheroma formation in castrated male animals, suggesting that testosterone may be antiatherosclerotic. 2 Alexandersen P. Haarbo J. Byrjalsen I. Lawaetz H. Christiansen C. Natural androgens inhibit male atherosclerosis a study in castrated, cholesterol fed rabbit. Circ Res. 1999; 84: 813-819 Crossref PubMed Scopus (232) Google Scholar In men with angina pectoris, a significant inverse correlation was found between plasma testosterone levels and the extent of CAD, demonstrating that low testosterone levels could be a risk factor for CAD. 3 Phillips G.B. Pinkernell B.H. Jing T.Y. The association of hypotestosteronemia with coronary artery disease in men. Arterioscler Thromb. 1994; 14: 701-706 Crossref PubMed Google Scholar Other reports suggest that testosterone replacement therapy in men with CAD has a beneficial effect on angina pectoris 4 Levine S.A. Likoff W.B. The therapeutic value of testosterone propionate in angina pectoris. N Engl J Med. 1943; 229: 770-772 Crossref Google Scholar , 5 Lesser M.A. Testosterone propionate therapy in one hundred cases of angina pectoris. J Clin Endocrinol. 1946; 6: 549-557 Crossref PubMed Scopus (63) Google Scholar and exercise-induced ST-segment depression. 6 Webb C.M. Adamson D.L. de Ziegler D. Collins P. Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol. 1999; 83: 437-439 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar , 7 Jaffe M.D. Effect of testosterone cypionate on postexercise ST segment depression. Br Heart J. 1977; 39: 1217-1222 Crossref PubMed Scopus (137) Google Scholar Another study showed that testosterone enhanced endothelium-independent coronary artery dilation and flow-mediated brachial arterial vasoreactivity in men with CAD. 8 Webb C.M. McNeill J.G. Hayward C.S. de Zeigler D. Collins P. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation. 1999; 100: 1690-1696 Crossref PubMed Scopus (383) Google Scholar , 9 Ong P.J.L. Patrizi G. Chong W.C.F. Webb C.M. Hayward C.S. Collins P. Testosterone enhances flow-mediated brachial artery reactivity in men with coronary artery disease. Am J Cardiol. 2000; 85: 269-272 Abstract Full Text Full Text PDF PubMed Scopus (121) Google Scholar In this study, we assessed the effects of oral testosterone administration on brachial arterial vasoreactivity in men with CAD.