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BIBTEX RIS

Angiotensin II increases periostin expression via Ras/p38 MAPK/CREB and ERK1/2/TGF-β1 pathways in cardiac fibroblasts

2011; Oxford University Press; Volume: 91; Issue: 1 Linguagem: Inglês

10.1093/cvr/cvr067

ISSN

1755-3245

Autores

Li Li, Fan Dong, Cheng Wang, Jinyu Wang, Xiao‐Bing Cui, Dan Wu, Yun Zhou, Li‐Ling Wu,

Tópico(s)

Peptidase Inhibition and Analysis

Resumo

AimsAngiotensin II (AngII) is involved in extracellular matrix (ECM) accumulation contributing to heart failure. Periostin, a 90 kDa ECM protein, is a key regulator of cardiac fibrosis, and its expression is significantly higher in failing hearts. We determined the modulatory effect of AngII on periostin level and explored the possible signal transduction mechanism.

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