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Near-Infrared Fluorescent NanoGUMBOS for Biomedical Imaging

2009; American Chemical Society; Volume: 3; Issue: 12 Linguagem: Inglês

10.1021/nn9010126

1936-086X

David K. Bwambok, Bilal El‐Zahab, Santhosh Challa, Min Li, Lin Chandler, Gary A. Baker, Isiah M. Warner,

Carbon and Quantum Dots Applications

Herein, we report on near-infrared (NIR) fluorescent nanoparticles generated from an emergent class of materials we refer to as a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are largely frozen ionic liquids, although the concept is more general and is also easily applied to solid ionic materials with melting points in excess of 100 °C. Nanoparticles based on GUMBOS (nanoGUMBOS) derived from a NIR fluorophore are prepared using a reprecipitation method and evaluated for in vivo fluorescence imaging. Due to their uniformity, single-step preparation, and composite nature, nanoGUMBOS help to resolve issues with dye leakage problems innate to alternate cellular stains and unlock a myriad of applications for these materials, highlighting exciting possibilities for multifunctional nanoGUMBOS.