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Efeito da fortificação de alimentos com ferro sobre anemia em crianças: um estudo de revisão

2007; Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz; Volume: 23; Issue: 2 Linguagem: Inglês

10.1590/s0102-311x2007000200003

1678-4464

Maria Cecília Formoso Assunção, Iná S. Santos,

Child Nutrition and Water Access

A systematic review was conducted to identify studies assessing the effect of food fortification with iron on childhood anemia. The MEDLINE, LILACS, and PubMed databases and WHO and PAHO sites were searched with no time limitation, including articles published in Portuguese, English, or Spanish, using the following key words and their combination: food fortification, iron, effectiveness, efficacy, anemia, flour, staple foods, interventions, and children. Of 21 studies reviewed, only one failed to report a positive, favorable effect of iron fortification, indicating the possibility of publication bias. The studies showed important methodological limitations. The two studies with the best methodological scores showed opposite results, highlighting the need for larger trials with better planning to explore this hypothesis.