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Total Synthesis of Marinomycins A–C

2006; Wiley; Volume: 45; Issue: 39 Linguagem: Inglês

10.1002/anie.200601867

1521-3773

K. C. Nicolaou, Andrea L. Nold, Robert R. Milburn, Corinna S. Schindler,

Asymmetric Synthesis and Catalysis

Ocean's three: Unearthed from the bottom of the ocean off the coast of La Jolla (California, USA), marinomycins A–C, which differ in geometry about the C8C9 and C8′C9′ double bonds, have been prepared by total synthesis through a strategy that features a Suzuki coupling reaction to forge their remarkable polyunsaturated 44-membered-ring systems (see picture). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601867_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.