Defining functional signatures of dysbiosis in periodontitis progression
2015; BioMed Central; Volume: 7; Issue: 1 Linguagem: Inglês
10.1186/s13073-015-0165-z
ISSN1756-994X
Autores Tópico(s)Salivary Gland Disorders and Functions
ResumoPeriodontitis is a common inflammatory disease that leads to tooth loss and has been linked to cardiovascular disease and diabetes mellitus. The periodontal microbiome is highly diverse, and metatranscriptomic studies have indicated that the genes that are expressed by the microbiota are more relevant than the microbial composition in the pathogenesis of periodontitis. A recent study of early metabolic activities in the dysbiotic microbiome reveals a functional signature that distinguishes periodontal sites that will become inflamed, supporting the idea that microbial communities as a whole drive disease progression.
Referência(s)