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Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania

1996; Oxford University Press; Volume: 90; Issue: 6 Linguagem: Inglês

10.1016/s0035-9203(96)90432-0

1878-3503

Jeffrey L. Curtis, Manoj T. Duraisingh, J. K. Trigg, Hadijah Mbwana, David C. Warhurst, C. F. Curtis,

Drug-Induced Hepatotoxicity and Protection

Journal Article Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania Get access J. Curtis, J. Curtis 1London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar M.T. Duraisingh, M.T. Duraisingh 1London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar J.K. Trigg, J.K. Trigg 1London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK2Ubwari Field Station, Box 81, Muheza, Tanga, Tanzania Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Mbwana, H. Mbwana 2Ubwari Field Station, Box 81, Muheza, Tanga, Tanzania Search for other works by this author on: Oxford Academic PubMed Google Scholar D.C. Warhurst, D.C. Warhurst 1London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar C.F. Curtis C.F. Curtis 1London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 90, Issue 6, November-December 1996, Pages 678–680, https://doi.org/10.1016/S0035-9203(96)90432-0 Published: 01 December 1996 Article history Received: 20 May 1996 Revision received: 17 July 1996 Accepted: 17 July 1996 Published: 01 December 1996