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Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class

2006; Wiley; Volume: 45; Issue: 13 Linguagem: Inglês

10.1002/anie.200503071

1521-3773

Richard K. Haynes, Burkhard Fugmann, Jörg Stetter, Karl H. Rieckmann, Hans‐Dietrich Heilmann, Ho‐Wai Chan, Man‐Ki Cheung, Wai‐Lun Lam, Ho Ning Wong, Simon L. Croft, Livia Vivas, Lauren Rattray, Lindsay B. Stewart, Wallace Peters, B. L. Robinson, Michael D. Edstein, Barbara Kotecka, Dennis E. Kyle, Bernhard Beckermann, Michael Gerisch, Martin Radtke, Gabriele Schmuck, Wolfram Steinke, Ute Wollborn, Karl Schmeer, A. Römer,

Research on Leishmaniasis Studies

Artemisinin—the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast to most current artemisinins it displays low lipophilicity and negligible neuro- and cytotoxicity in in vitro and in vivo assays. Thus, the drug offers promise for use in artemisinin-based combination therapy. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503071_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.