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Sleep Drives Metabolite Clearance from the Adult Brain

2013; American Association for the Advancement of Science; Volume: 342; Issue: 6156 Linguagem: Inglês

10.1126/science.1241224

1095-9203

Lulu Xie, Hongyi Kang, Qiwu Xu, Michael Chen, Yonghong Liao, Meenakshisundaram Thiyagarajan, John O’Donnell, Daniel J. Christensen, Charles Nicholson, Jeffrey J. Iliff, Takahiro Takano, Rashid Deane, Maiken Nedergaard,

Sleep and related disorders

Taking Out the Trash The purpose of sleep remains mysterious. Using state-of-the-art in vivo two-photon imaging to directly compare two arousal states in the same mouse, Xie et al. (p. 373 ; see the Perspective by Herculano-Houzel ) found that metabolic waste products of neural activity were cleared out of the sleeping brain at a faster rate than during the awake state. This finding suggests a mechanistic explanation for how sleep serves a restorative function, in addition to its well-described effects on memory consolidation.