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Cycloartane Glycosides from the Rhizomes of Cimicifuga racemosa and Their Cytotoxic Activities.

2002; Pharmaceutical Society of Japan; Volume: 50; Issue: 1 Linguagem: Inglês

10.1248/cpb.50.121

1347-5223

Kazuki Watanabe, Yoshihiro Mimaki, Hiroshi Sakagami, Yutaka Sashida,

Natural product bioactivities and synthesis

Phytochemical analysis of the rhizomes of Cimicifuga racemosa (Ranunculaceae) resulted in the isolation of twelve cycloartane glycosides (1--12), including four new ones (4--6, 12). The structures of the new compounds were determined by spectroscopic analysis, including two-dimensional (2D) NMR data, and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against human oral squamous cell carcinoma (HSC-2) cells and normal human gingival fibroblasts (HGF).