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Three‐Component Reaction Using the Bestmann–Ohira Reagent: A Regioselective Synthesis of Phosphonyl Pyrazole Rings

2010; Wiley; Volume: 49; Issue: 18 Linguagem: Inglês

10.1002/anie.200906781

1521-3773

Kishor Mohanan, Anthony R. Martin, Loı̈c Toupet, Michaël Smietana, Jean‐Jacques Vasseur,

Synthesis and biological activity

BOR-n to run: A new one-pot multicomponent reaction involving the use of an aldehyde, a cyanoacid derivative, and the Bestmann–Ohira reagent (BOR) has been developed for the synthesis of substituted phosphonyl pyrazoles. This process was also combined with a copper-catalyzed azide–alkyne 1,3-dipolar cycloaddition to generate five new bonds and two heterocyclic rings in a one-pot fashion. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.