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Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

2006; National Academy of Sciences; Volume: 103; Issue: 44 Linguagem: Inglês

10.1073/pnas.0607822103

1091-6490

Pamela Maher, Tatsuhiro Akaishi, Kazuho Abe,

Cholinesterase and Neurodegenerative Diseases

Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.