Produção Nacional
Revisado por pares
Ocorrência e diversidade estrutural de metabólitos fúngicos com atividade antibiótica
2008; Brazilian Chemical Society; Volume: 31; Issue: 7 Linguagem: Inglês
10.1590/s0100-40422008000700036
ISSN1678-7064
AutoresJacqueline A. Takahashi, Esther Maria Ferreira Lucas,
Tópico(s)Phytochemistry and Bioactivity Studies
ResumoFUNGAL METABOLITES WITH ANTIBIOTIC ACTIVITY.Several reasons motivated the development of new generations of antibiotics, such as their high ability to develop resistance to virtually all kinds of anti-infective agents and the crescent market demand for new drugs to treat special demanding patients.After penicillin discovery, several antibiotics were developed from fungal metabolites, since antibacterial secondary metabolites consists on a fungal endogenous protective mechanism against natural competitors.The aim of this review is to present the structural diversity of antibacterial and antifungal metabolites produced by fungi, mentioning sources of fungal isolates, cultivation process and details on the scope of their antibiotic activity.
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