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BIBTEX RIS

New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis

2005; Brazilian Chemical Society; Volume: 16; Issue: 6b Linguagem: Inglês

10.1590/s0103-50532005000800029

ISSN

1678-4790

Autores

Geraldo Humberto Silva, Helder Lopes Teles, Henrique C. Trevisan, Vanderlan da Silva Bolzani, Maria Cláudia Marx Young, Ludwig H. Pfenning, Marcos N. Eberlin, Renato Haddad, Claudio M. Costa‐Neto, Ângela R. Araújo,

Tópico(s)

Phytochemistry and Biological Activities

Resumo

Two new metabolites, ethyl 2,4-dihydroxy-5,6-dimethylbenzoate (1) and phomopsilactone (2) were isolated from Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Their structures were elucidated by 1D and 2D NMR, MS and IR spectral data. Compounds 1 and 2 displayed strong antifungal activity against the phytopatogenic fungi Cladosporium cladosporioides and C. sphaerospermum, as well as cytotoxicity against human cervical tumor cell line (HeLa), in in vitro assays.

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