Artificial Anthraquinone–Carbohydrate Hybrids: Design, Synthesis, DNA Binding, and Cytotoxicity
1997; Wiley; Volume: 36; Issue: 24 Linguagem: Inglês
10.1002/anie.199727481
ISSN1521-3773
AutoresKazunobu Toshima, Hiromi Ouchi, Yoriko Okazaki, Takaaki Kano, MAKOTO MORIGUCHI, Shuichi Matsumura, Akira Asai,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoAngewandte Chemie International Edition in EnglishVolume 36, Issue 24 p. 2748-2750 Communication Artificial Anthraquinone–Carbohydrate Hybrids: Design, Synthesis, DNA Binding, and Cytotoxicity† Prof. Dr. Kazunobu Toshima, Corresponding Author Prof. Dr. Kazunobu Toshima Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpDepartment of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3–14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563–0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorHiromi Ouchi, Hiromi Ouchi Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorYoriko Okazaki, Yoriko Okazaki Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorTakaaki Kano, Takaaki Kano Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorMakoto Moriguchi, Makoto Moriguchi Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorProf. Dr. Shuichi Matsumura, Prof. Dr. Shuichi Matsumura Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorAkira Asai, Akira Asai Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Tokyo (Japan)Search for more papers by this author Prof. Dr. Kazunobu Toshima, Corresponding Author Prof. Dr. Kazunobu Toshima Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpDepartment of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3–14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563–0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorHiromi Ouchi, Hiromi Ouchi Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorYoriko Okazaki, Yoriko Okazaki Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorTakaaki Kano, Takaaki Kano Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorMakoto Moriguchi, Makoto Moriguchi Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorProf. Dr. Shuichi Matsumura, Prof. Dr. Shuichi Matsumura Department of Applied Chemistry, Faculty of Sceince and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223 (Japan), Fax: Int. code + (45)563-0446, e-mail: toshima@applc.keio.ac.jpSearch for more papers by this authorAkira Asai, Akira Asai Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Tokyo (Japan)Search for more papers by this author First published: January 7, 1997 https://doi.org/10.1002/anie.199727481Citations: 27 † This research was partially supported by a Grant-in-Aid for Scientific Research on Priority Area No. 08219236 from the Ministry of Education, Sciene, Sports, and Culture, Japan. We thank Mr. Naoyuki Hiraoka (Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.) for his skillful technical assistance. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Intercalation and sequence selectivity characterize the binding of the anthraquinone–carbohydrate hydrid 1 to DNA. Important for this binding and for the cytotoxicity of 1 is the hybrid structure, which is based on that of several natural antitumor antibiotics. The enantiomer of 1 is about six times less cytotoxic because of its distinctly reduced intercalation potential. Citing Literature Volume36, Issue24January 7, 1997Pages 2748-2750 RelatedInformation
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