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Receptor for Motilin Identified in the Human Gastrointestinal System

1999; American Association for the Advancement of Science; Volume: 284; Issue: 5423 Linguagem: Inglês

10.1126/science.284.5423.2184

1095-9203

Scott D. Feighner, Carina P. Tan, Karen K. McKee, Oksana Palyha, Donna L. Hreniuk, Sheng‐Shung Pong, Christopher P. Austin, David J. Figueroa, Douglas J. MacNeil, Margaret A. Cascieri, Ravi P. Nargund, Raman K. Bakshi, Mark Abramovitz, Rino Stocco, Stacia Kargman, Gary P. O’Neill, Lex H. T. Van Der, Ploeg, Jilly F. Evans, Arthur A. Patchett, Roy G. Smith, Andrew D. Howard,

Diet and metabolism studies

Motilin is a 22-amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract of humans and other species. It affects gastric motility by stimulating interdigestive antrum and duodenal contractions. A heterotrimeric guanosine triphosphate-binding protein (G protein)-coupled receptor for motilin was isolated from human stomach, and its amino acid sequence was found to be 52 percent identical to the human receptor for growth hormone secretagogues. The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI tract. The motilin receptor is expressed in enteric neurons of the human duodenum and colon. Development of motilin receptor agonists and antagonists may be useful in the treatment of multiple disorders of GI motility.