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Draft Genome Sequence of the Sexually Transmitted Pathogen Trichomonas vaginalis

2007; American Association for the Advancement of Science; Volume: 315; Issue: 5809 Linguagem: Inglês

10.1126/science.1132894

1095-9203

Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael C. Schatz, Qi Zhao, Jennifer R. Wortman, Shelby Bidwell, U. Cecilia M. Alsmark, Sébastien Besteiro, Thomas Sicheritz‐Pontén, Christophe Noël, Joel B. Dacks, Peter G. Foster, Cédric Simillion, Yves Van de Peer, Diego Miranda‐Saavedra, Geoffrey J. Barton, Gareth D. Westrop, Sylke Müller, Daniele Dessì, Pier Luigi Fiori, Qinghu Ren, Ian T. Paulsen, Hanbang Zhang, Felix Bastida, Augusto Simões-Barbosa, Mark T. Brown, Richard D. Hayes, Mandira Mukherjee, Cheryl Okumura, Rachel Schneider, Alias Smith, Štěpánka Vaňáčová, Maria Villalvazo, Brian J. Haas, Mihaela Pertea, Tamara V. Feldblyum, Terry Utterback, Chung-Li Shu, Kazutoyo Osoegawa, Pieter J. de Jong, Ivan Hrdý, Lenka Horváthová, Zuzana Zubáčová, Pavel Doležal, Shehre-Banoo Malik, John M. Logsdon, Katrin Henze, Arti Gupta, Ching C. Wang, Rebecca Dunne, Jacqueline Upcroft, Peter Upcroft, Owen White, Steven L. Salzberg, Petrus Tang, Cheng‐Hsun Chiu, Ying‐Shiung Lee, T. Martin Embley, Graham H. Coombs, Jeremy C. Mottram, Jan Tachezy, Claire M. Fraser, Patricia J. Johnson,

Toxoplasma gondii Research Studies

We describe the genome sequence of the protist Trichomonas vaginalis , a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.