Portal de Periódicos da CAPES

Maternal Immunologic and Virologic Risk Factors for Infant Human Immunodeficiency Virus Type 1 Infection: Findings from the Women and Infants Transmission Study

1997; Oxford University Press; Volume: 175; Issue: 3 Linguagem: Inglês

10.1093/infdis/175.3.567

1537-6613

Jane Pitt, Donald Brambilla, Patricia Reichelderfer, Alan Landay, Kenneth McIntosh, David Burns, George V. Hillyer, Hermann Mendez,

HIV/AIDS drug development and treatment

Maternal virus load of human immunodeficiency virus 1 (HIV-l) and maternal immunity are both associated with risk of an infected infant. The interrelationship of these two variables in describing that risk was assessed in a multisite study of 475 mother-infant pairs. Infant infection was associated with low CD4 cell percentage, high CD8, CD8/CD38, and CD8/DR cell percentages, persistently positive HIV-l cultures, and high HIV-l titer (P < .001, .001, .005, .006, .001, and .013, respectively). The association of CD4 cell percentage and increased CD8, CD8/CD38, and CD8/DR cell percentages with transmission was restricted to the 42% of women whose HIV-l cultures were not persistently positive (all P < .001).Women with at least 1 negative culture and high CD4 cell percentage or low CD8 cell percentage were at very low risk (0–4%) of transmitting HIV-l, while those with always positive cultures transmitted at a high rate (18%–27%), regardless of immune status.