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Activation of the Cytokine Network and Unfavorable Outcome in Patients with Yellow Fever

2004; Oxford University Press; Volume: 190; Issue: 10 Linguagem: Inglês

10.1086/425016

1537-6613

Jan ter Meulen, Mohamed Sakho, Kékoura Koulemou, N’Faly Magassouba, Aissatou Kenda Bah, Wolfgang Preiser, Stéphane Daffis, Christian Klewitz, Hi‐Gung Bae, Matthias Niedrig, H. Zeller, Monika Heinzel‐Gutenbrunner, Lamine Koivogui, Andreas M. Kaufmann,

Viral Infections and Outbreaks Research

To study the contribution of inflammatory mediators to the pathogenesis of yellow fever (YF), the serum levels of several cytokines and chemokines were measured in 7 patients with fatal YF (f-YF), 11 patients with nonfatal hemorrhagic YF (nf/h-YF), and 18 patients with nonfatal nonhemorrhagic YF (nf/nh-YF). The levels of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-inducible protein (IP)-10, tumor necrosis factor- alpha , and IL-1 receptor antagonist (IL-1RA) were all statistically significantly higher in the patients with f-YF than in those with nf/nh-YF. In patients with nf/h-YF, only levels of IP-10 and IL-1RA were significantly elevated. The high levels of pro- and anti-inflammatory cytokines and chemokines in serum from patients with f-YF are reminiscent of those seen in patients with bacterial sepsis. This finding has implications for the understanding of the pathophysiology of YF and the development of therapeutic strategies.