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Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections

2010; Multidisciplinary Digital Publishing Institute; Volume: 16; Issue: 1 Linguagem: Inglês

10.3390/molecules16010190

1433-1373

Victor Alves Carneiro, Hélcio Silva dos Santos, Francisco Vassiliepe Sousa Arruda, Paulo Nogueira Bandeira, Maria Rose Jane R. Albuquerque, Maria Olívia Pereira, Mariana Henriques, Benildo Sousa Cavada, Edson Holanda Teixeira,

Bacterial biofilms and quorum sensing

Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.