Portal de Periódicos da CAPES

Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome

2014; Informa; Volume: 28; Issue: 15 Linguagem: Inglês

10.3109/14767058.2014.968843

1476-7058

Nathalie Conti, Gabriele Cevenini, Silvia Vannuccini, Cinzia Orlandini, Herbert Valensise, Maria Teresa Gervasi, Fabio Ghezzi, Mariarosaria Di Tommaso, Filiberto Maria Severi, Felice Petraglia,

Ectopic Pregnancy Diagnosis and Management

To evaluate pregnancy, delivery and neonatal outcome in singleton primiparous versus multiparous women with/without endometriosis.Multicentric, observational and cohort study on a group of Caucasian pregnant women (n = 2239) interviewed during their hospitalization for delivery in five Italian Gynecologic and Obstetric Units (Siena, Rome, Padua, Varese and Florence).Primiparous women with endometriosis (n = 219) showed significantly higher risk of small for gestational age fetuses (OR: 2.72, 95% CI 1.46-5.06), gestational diabetes (OR: 2.13, 95% CI 1.32-3.44), preterm premature rupture of membranes (OR: 2.93, 95% CI 1.24-6.87) and preterm birth (OR: 2.24, 95% CI 1.46-3.44), and were hospitalized for a longer period of time (p < 0.0001) comparing with control group (n = 1331). Multiparous women with endometriosis (n = 97) delivered significantly more often small for gestational age fetuses (OR: 2.93, 95% CI 1.28-6.67) than control group (n = 592). Newborns of primiparous women with endometriosis needed more frequently intensive care (p = 0.05) and were hospitalized for a longer period of time (p < 0.0001).Women with endometriosis at first pregnancy have an increased risk of impaired obstetric outcome, while a reduced number of complications occur in the successive gestation. Therefore, it is worthy for obstetricians to increase the surveillance in nulliparous women with endometriosis during pregnancy.