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Diagnosis and treatment of pyoderma gangrenosum

2006; BMJ; Volume: 333; Issue: 7560 Linguagem: Inglês

10.1136/bmj.333.7560.181

0959-8138

Trevor Brooklyn, Giles Dunnill, Chris Probert,

Syphilis Diagnosis and Treatment

Pyoderma gangrenosum is a rare but serious ulcerating skin disease, the treatment of which is mostly empirical.Pyoderma can present to a variety of health professionals and several variants exist that may not be recognised immediately.This can delay the diagnosis and have serious clinical consequences. 1The mainstay of treatment is long term immunosuppression, often with high doses of corticosteroids or low doses of ciclosporin.Recently, good outcomes have been reported for treatments based on anti-tumour necrosis factor , and infliximab proved effective in a randomised controlled trial.This article reviews the presentation of pyoderma gangrenosum and the therapeutic options available. MethodsWe used the keyword "pyoderma gangrenosum" to search Medline.We also searched the Cochrane database but found no Cochrane review on this disease.