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Production of 19S IgM Antibodies with Restricted Heterogeneity from Sharks

1971; National Academy of Sciences; Volume: 68; Issue: 1 Linguagem: Inglês

10.1073/pnas.68.1.139

1091-6490

L. William Clem, Gerrie A. Leslie,

Glycosylation and Glycoproteins Research

Two of three nurse sharks, Ginglymostoma cirratum, immunized with streptococcal A-variant vaccine, produced over 7 mg/ml serum of 19S IgM antibody to the group-specific carbohydrate. The light chains of this specific antibody from one shark were separated into multiple bands by disc electrophoresis. The light chains from the other antibody-producing animal were much less heterogeneous and gave only one predominant band.