Measurements of Plasma Methoxytyramine, Normetanephrine, and Metanephrine as Discriminators of Different Hereditary Forms of Pheochromocytoma
2011; American Association for Clinical Chemistry; Volume: 57; Issue: 3 Linguagem: Inglês
10.1373/clinchem.2010.153320
ISSN1530-8561
AutoresGraeme Eisenhofer, Jacques W.M. Lenders, Henri Timmers, Massimo Mannelli, Stefan K. Grebe, Lorenz C. Hofbauer, Stefan R. Bornstein, Oliver Tiebel, Karen T. Adams, Gennady Bratslavsky, W. Marston Linehan, Karel Pacák,
Tópico(s)Pituitary Gland Disorders and Treatments
ResumoPheochromocytomas are rare catecholamine-producing tumors derived in more than 30% of cases from mutations in 9 tumor-susceptibility genes identified to date, including von Hippel-Lindau tumor suppressor (VHL); succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB); and succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD). Testing of multiple genes is often undertaken at considerable expense before a mutation is detected. This study assessed whether measurements of plasma metanephrine, normetanephrine, and methoxytyramine, the O-methylated metabolites of catecholamines, might help to distinguish different hereditary forms of the tumor.
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