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Copper‐Catalyzed Amidation of Acids Using Formamides as the Amine Source

2013; Wiley; Volume: 2013; Issue: 25 Linguagem: Inglês

10.1002/ejoc.201300543

1434-193X

Ye‐Xiang Xie, Ren‐Jie Song, Xu‐Heng Yang, Jiannan Xiang, Jin‐Heng Li,

Advanced Synthetic Organic Chemistry

Abstract Copper‐catalyzed amidation of acids with formamides or acetamide for the selective synthesis of amides with the aid of 1,4‐diazabicyclo[2.2.2]octane as the ligand and tert ‐butyl hydroperoxide as the oxidant is presented. This method is highly compatible with a wide range of acids, including alkyl acids, aryl acids, α,β‐unsaturated acids, and amino acids.