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Association of Cigarette Smoking with Extraprostatic Prostate Cancer in Young Men

2003; Lippincott Williams & Wilkins; Volume: 169; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(05)63945-6

1527-3792

William W. Roberts, Elizabeth A. Platz, Patrick C. Walsh,

Genomics, phytochemicals, and oxidative stress

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Feb 2003Association of Cigarette Smoking with Extraprostatic Prostate Cancer in Young Men WILLIAM W. ROBERTS, ELIZABETH A. PLATZ, and PATRICK C. WALSH WILLIAM W. ROBERTSWILLIAM W. ROBERTS , ELIZABETH A. PLATZELIZABETH A. PLATZ , and PATRICK C. WALSHPATRICK C. WALSH View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)63945-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: A few recent studies have revealed that cumulative or recent smoking is associated with death from prostate cancer suggesting that smoking may influence progression to more advanced disease. We evaluate the association of cigarette smoking with extraprostatic and/or Gleason sum 7 or greater prostate cancer in young men. Materials and Methods: The study included men who underwent radical prostatectomy before age 55 years for prostate cancer between 1992 and 1999. A survey soliciting cigarette smoking history and other exposures was mailed to 498 eligible men. The response rate was 73%. Cases were defined as men with Gleason sum 7 or greater, extraprostatic or Gleason sum 7 or greater/extraprostatic disease based on pathologic analysis. All remaining participants were considered noncases for each case definition. We used logistic regression modeling to estimate the odds ratio (OR) for Gleason sum 7 or greater, extraprostatic and Gleason sum 7 or greater/extraprostatic disease with cigarette smoking. Results: Of the 352 respondents with a cigarette smoking history 5.4% were current smokers and 44.6% were former smokers at the time of surgery. The odds ratios of extraprostatic and Gleason sum 7 or greater/extraprostatic disease were 3.85 (95% CI 1.44–10.33) and 3.17 (95% CI = 1.13–8.85), respectively, for current smokers compared to men who never smoked. Evidence of an association of smoking with Gleason sum 7 or greater disease was limited. Risk of extraprostatic (p = 0.005) and Gleason sum 7 or greater/extraprostatic (p = 0.003) disease increased with increasing cumulative pack-years smoked. Higher cumulative smoking in the 10 years before surgery was associated with an increased risk of extraprostatic (p = 0.004) and Gleason sum 7 or greater/extraprostatic (p = 0.005) disease. Conclusions: Cigarette smoking may influence the risk of extraprostatic prostate cancer in young men. References 1 : The epidemiology of prostate cancer part II: the risk factors. Semin Urol Oncol1998; 16: 193. Google Scholar 2 : Risk factors for prostate cancer. Ann Intern Med1993; 118: 793. Google Scholar 3 : Studies of Japanese migrants I. 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Google Scholar From The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, the Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byTaneja S (2018) Re: Association of Cigarette Smoking and Smoking Cessation with Biochemical Recurrence of Prostate Cancer in Patients Treated with Radical ProstatectomyJournal of Urology, VOL. 194, NO. 5, (1285-1286), Online publication date: 1-Nov-2015.PICKLES T, LIU M, BERTHELET E, KIM-SING C, KWAN W and TYLDESLEY S (2018) THE EFFECT OF SMOKING ON OUTCOME FOLLOWING EXTERNAL RADIATION FOR LOCALIZED PROSTATE CANCERJournal of Urology, VOL. 171, NO. 4, (1543-1546), Online publication date: 1-Apr-2004.OEFELEIN M and RESNICK M (2018) ASSOCIATION OF TOBACCO USE WITH HORMONE REFRACTORY DISEASE AND SURVIVAL OF PATIENTS WITH PROSTATE CANCERJournal of Urology, VOL. 171, NO. 6 Part 1, (2281-2284), Online publication date: 1-Jun-2004. Volume 169Issue 2February 2003Page: 512-516 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordssmokingprostatic neoplasmstobaccoMetricsAuthor Information WILLIAM W. ROBERTS More articles by this author ELIZABETH A. PLATZ More articles by this author PATRICK C. WALSH More articles by this author Expand All Advertisement PDF downloadLoading ...