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Inhibitory Effect of Stevioside on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-acetate in Two-Stage Carcinogenesis in Mouse Skin.

2002; Pharmaceutical Society of Japan; Volume: 25; Issue: 11 Linguagem: Inglês

10.1248/bpb.25.1488

1347-5215

Ken Yasukawa, Susumu Kitanaka, Shujiro Seo,

Biological Activity of Diterpenoids and Biflavonoids

Four steviol (ent-kaurene-type diterpenoid) glycosides, stevioside, rebaudiosides A and C, and dulcoside A, have been isolated from Stevia rebaudiana BERTONI. These compounds showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 54.1—291.6 μg/ear. Furthermore, at 1.0 and 0.1 mg/mouse of stevioside mixture, the mixture of these compounds markedly inhibited the promoting effect of TPA (1 μg/mouse) on skin tumor formation initiated with 7,12-dimethylbenz[a]anthracene (50 μg/mouse).